The clinical stage was IV A by the Ann Arbor staging system. A final diagnosis was made through deep resection. HHS Vulnerability Disclosure, Help On this Wikipedia the language links are at the top of the page across from the article title. https://doi.org/10.1186/s13000-020-00936-w, DOI: https://doi.org/10.1186/s13000-020-00936-w. Etemad-Moghadam S, Tirgary F, Keshavarz S, Alaeddini M. Head and neck non-Hodgkin's lymphoma: a 20-year demographic study of 381 cases. However, HPV infections have been identified with increasing frequency in patients with oropharyngeal squamous cell carcinoma, which is a predisposing risk factor [29]. Sun J, Lu Z, Yang D, Chen J. 1999;26:33845. B. C. Jham, N. O. Binmadi, M. A. Scheper et al., Follicular lymphoid hyperplasia of the palate: case report and literature review, Journal of Cranio-Maxillofacial Surgery, vol. Pathobiology. Tongue base lymphoid hyperplasia, also known as pseudolymphoma, is an uncommon benign entity associated with a rapid increase in the abundance of lymphocytes contained within or outside of lymph nodes. The term reactive lymphoid hyperplasia (RLH) is used as a general term to describe these types of lymphoid proliferations. Of the 6 B-cell NHL cases, 5 were DLBCLs and 1 was MCL. .. Lewis JS Jr. Morphologic diversity in human papillomavirus-related oropharyngeal squamous cell carcinoma: catch me if you can! In the study of Eisuke et al., hypermethylation of the p16 promotor indicated a poor prognosis [35]. 2014;10:94550. 8600 Rockville Pike Is it always necessary to carry out a biopsy on lymphoid hyperplasia or is endoscopic examination and MRI enough to decide that it is benign? PubMed After washing and amplification, target RNA was stained with DAB. Severe HBT was considered to be present when the follicles prevented the view of the epiglottis or were massively distributed through the pharynx and larynx. The other two cases were mantle cell lymphoma (MCL) and peripheral T cell lymphoma, not otherwise specified (PTCL, NOS). TIA, SOX10 was obtained from Beijing XiYaJinQiao Biological Technology Co. Ltd. China. 1993;189:30011. No progression to malignancy has been reported, although one multisite case within the oral cavity was found to represent MALT-type lymphoma [1]. These tissues act as your body's first line of defense against infections. Authors M Gromet , M J Homer , B L Carter PMID: 7111732 DOI: 10.1148/radiology.144.4.7111732 No abstract available Publication types Case Reports MeSH terms Adult Barium Sulfate Deglutition Diagnosis, Differential Female FISH detection found that one case had a single Bcl-2 rearrangement and one case had a single Bcl-6 rearrangement. Aggregates of lymphoid tissue are all over the oral mucosa, but they are often prominent in the soft palate, uvula, and pharynx. She is founder and cohost of the International Oral Lichen Planus Support Group (dentistry.tamhsc.edu/olp) and coauthor of General and Oral Pathology for the Dental Hygienist, now in its third edition. A mass was identified in the right base of the tongue that caused breathing difficulties. When we think of lymphoid hyperplasia in the oral cavity, we often think of localized increases of lymph node tissue. Clinically this lesion presented as a painless ulcer, which mimicked carcinoma of the tongue. Her chemotherapy regimen was changed to GDP. and transmitted securely. However, HCV infection did not have a significant impact on the overall survival or event-free survival of DLBCL patients [31].HPV infection developing in this site might be due to low immunity from B cell lymphoma or HPV contributing to the development of lymphoma. 2009 Sep;114(6):948-59. doi: 10.1007/s11547-009-0416-4. Dental professionals should pay close attention to these areas of the mouth due to the possibility of oral cancer, which is being increasingly seen at the base of the tongue and in the oropharynx. Nancy W. Burkhart, EdD, BSDH, AFAAOM, is an adjunct associate professor in the Department of Periodontics-Stomatology, College of Dentistry, Texas A&M University, Dallas, Texas. This study was supported by grants from CAMS Initiative for Innovative Medicine (CAMS-I2M) (2016-I2M-1-002). The obstructive lesion was biopsied, and specimens were sent fresh for lymphoma histopathology protocol. Epub 2009 Jun 26. We not only report on the general clinicopathological features, including age, gender, tumour location, histological subtypes, grading and staging, but also provide important information related to prognosis and treatment. https://doi.org/10.1038/modpathol.2011.45. 1. But when areas of focal nodular lymphoid hyperplasiawhich are well-known to occur in other areas of the bodyoccur in the mouth, they create a perplexing dilemma for dental professionals. 88, no. Epub 2018 Jun 25. Differential diagnoses include benign lymphoid hyperplasia and carcinoma. Never disregard or delay professional medical advice in person because of anything on HealthTap. As seen in Figure 1, the soft palate, uvula, and posterior pharynx demonstrate multiple areas of enlargement that are consistent with lymphoid tissue. 2013;91 Thesis 5:127. 2001;23:54758. 2010;39:86972. Federal government websites often end in .gov or .mil. Cytoplasmic staining was used for ALK, TIA, AE1/AE3. K. F. Adkins, Lymphoid hyperplasia in the oral mucosa, The Australian Dental Journal, vol. Unauthorized use of these marks is strictly prohibited. Clipboard, Search History, and several other advanced features are temporarily unavailable. HIV serology was negative. Two years later, after the sixth cycle of chemotherapy, the patient was admitted to the emergency room for choking. [2], A lymph node is small, capsulated lymphoid organ that is present along the lymphatic system. Although the head and neck region is the second most frequent anatomical site of extranodal lymphomas beside the gastrointestinal tract, lymphomas primarily located in the tongue base are noted in the literature to be rare [16, 17]. These included 196 cases of extranodal lymphoma (NHL) occurring in the head and neck, among which seven cases arose from the base of tongue. https://doi.org/10.1182/blood-2003-05-1545. Briefly, 2- to 3-mm thick FFPE tissue sections were deparaffinized, heated, treated with a protease and H2O2 plus and hybridized with the probe at 40C for 2h plus Amp16. What are chaces of malignancy?What precautions for future shud i take? J Postgrad Med. https://doi.org/10.4149/BLL_2017_116. Google Scholar. Four treatment response classes were defined, as follows: complete response (CR, 100% resolution); partial response (PR, 50100% resolution); no response (<50% resolution); and progression of disease (PD, tumour enlarged after treatment). https://doi.org/10.11406/rinketsu.58.2033. The surface of the tongue in this area is made up primarily of lymphoid tissue known as the lingual tonsil. Clinically this lesion presented as a painless ulcer, which mimicked carcinoma of the tongue. By that time, and at one week after discharge, the pharynx appeared within normal limits. 349356, 1980. All DLBCL cases were positive for CD20, Mum1,Bcl-2 and Bcl-6 and negative for CD5. Rinsho Ketsueki. Reference Sands and Tewfik 1 The aetiology is poorly understood, . To learn more, please visit our, Internal Medicine - Hematology & Oncology, It means that there is an increase of the number of a type of white, called lymphocytes. Cookies policy. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). a. H&E showed a diffuse infiltrate of large cells with an obvious nucleolus and abundant cytoplasm (200 x). This may have been due to the expression of the cytotoxic marker TIA, Granzyme B, and a much higher Ki-67 index (80%), which may indicate a poor prognosis [41]. Bone marrow involvement was identified at relapse. Lymphoid hyperplasia of the tongue is a very rare benign lymphoproliferative lesion that closely resembles carcinoma or lymphoma, clinically or histopathologically. Synchronous cancers in patients with head and neck cancer: risks in the era of human papillomavirus-associated oropharyngeal cancer. Copyright 2011 Noah B. Sands and Marc Tewfik. J Clin Oncol. Lymphoid hyperplasia of the tongue is a very rare benign lymphoproliferative lesion that closely resembles carcinoma or lymphoma, clinically or histopathologically. 2005;23:2797804. These tonsils contain B and T lymphocytes which get activated when harmful bacteria and viruses come in contact with tonsils. 2009 Mar-Apr;75(2):195-9. doi: 10.1016/s1808-8694(15)30778-3. showed that loss of P16 expression has no effect on life expectancy [33], but high P16 levels may inhibit tumour growth in DLBCL [34]. There is usually a bilateral . Russo S, Lo Re G, Galia M, Reginelli A, Lo Greco V, D'Agostino T, La Tona G, Coppolino F, Grassi R, Midiri M, Lagalla R. Radiol Med. 2023 Endeavor Business Media, LLC. Maheshwari GK, Baboo HA, Gopal U, Wadhwa MK. Samples were assayed using a BOND HPV probe set specific to HPV subtypes 16, 18, 31, 33 and 51 (Bond Ready-to-Use ISH HPV Probe, CAT # PB0829) on the Leica BOND-MAX system. Lymphomas of the head and neck: CT findings at initial presentation. These results all indicate that HPV positivity does not have much impact on the overall survival of DLBCL patients. The exceptional case here was a 45-year-old male patient with diffuse large B cell lymphoma who presented with only deep painful mouth ulcers and general symptoms, including sore throat, choking when drinking water, and difficulty swallowing. As both peripheral T cell lymphoma and MCL are extremely rare in the tongue base, we would like to describe these two cases in detail as follows. Pribuisiene R, Uloza V, Siupsinskiene N, Butkus E, Kupcinskas L. Al-Asoom L, Al-Rubaish AM, El-Munshid HA, Al-Nafaie AN, Bukharie HA, Abdulrahman IS. All 7 lymphomas were localized at the base of the tongue. Lymphoid Hyperplasia Pulmonary lymphoid hyperplasia, also known as follicular bronchiolitis, is an uncommon, benign condition characterized histologically by the presence of polyclonal lymphoid aggregates along the bifurcation of the bronchioles and along the pulmonary lymphatics. Blood. All cases were reviewed and diagnoses were confirmed based on basic morphology, immunohistochemistry staining, and rearrangement. 2000 Apr;122(4):607-10. doi: 10.1067/mhn.2000.98362. For immunoglobulin gene rearrangement, we used IdentiClone IGH, IGK and IGL Gene Clonality assays with gel detection (InVivoScribe Technologies, San Diego, CA, USA). Head and neck extranodal lymphoma in a single institute: a 17-year retrospective analysis. https://doi.org/10.1309/YHFE-R65B-D3LK-3GGV. 4 Metrics Downloaded 279 times PDF download Overall, the tumour cells were generally small to medium with irregular nuclei. Dr. Tarik Hadid answered Internal Medicine - Hematology & Oncology 20 years experience Benign: It means that there is an increase of the number of a type of white blood cells called lymphocytes. Work-up of globus: assessing the benefits of neck ultrasound and videofluorography. https://doi.org/10.1093/jnci/djn011. Final pathology was determined on postoperative day (POD) 2 to be benign follicular/intrafollicular lymphoid hyperplasia characterized by polyclonal lymphoid proliferation with an inflammatory background. This conditions means you have a increase in their number which is a benign condition as the name implies.. What is the treatment of reactive lymphoid hyperplasia? The patient received two cycles of GDP (gemcitabine, dexamethasone, cisplatin) and seven cycles of CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone) chemotherapy. Head Neck. Abstract Background Benign lymphoid hyperplasia (BLH) is a benign proliferation of lymphoid tissue in response to external irritation. Although they were in different stages, their prognosis was similarly good. Lymphoid hyperplasia at the base of the tongue. a. MRI showed a mass in the base of the tongue sticking to the pharyngeal cavity and making it obviously narrow. Leuk Res. 2023 BioMed Central Ltd unless otherwise stated. Paracortical hyperplasia may be accompanied by vascular proliferation. Acta Ophthalmol. 39, no. The tumour cells were large and blastic, with a high mitotic rate, which was similar to diffuse large B lymphoma tumour cells. When the lymphoid tissue is deeply seated, the appearance may be more pink or deeper in color. For future shud i take advanced features are temporarily unavailable the tongue in this area is made primarily. 4 ):607-10. doi: 10.1067/mhn.2000.98362 carcinoma of the p16 promotor indicated a poor prognosis [ 35 ] benign! 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